Novel, safe and sensitive methods for the titrimetric estimation of phenylbutazone bulk drug have been developed using 2 M sodium benzoate solution and 1 M ibuprofen sodium solution as hydrotropic solubilizing agents. The enhancement in aqueous solubility of phenylbutazone bulk drug was more than 51-folds and 164-folds when sodium benzoate and ibuprofen sodium hydrotropic solutions were used respectively. Results of the analysis were validated statistically. The results of analysis obtained by the proposed methods were very comparable with the results of analysis obtained by the Indian Pharmacopoeial method.
Loading....